This study was carried out to study the preventive effect, of phenylalanine on the toxicities of ochratoxin A to the mortalites, hematological and serum biochemical values.
A single dose of ochratoxin A(69.4㎎/㎏ B.W., P.O) was given W male ICR mice and its toxicities were evaluated by body weight changes, autopary findings, organ weight, and hematological and serum biochemical parameters.
The single dose of ochratoxin A caused significant different from vehicle control values in mortality, body weight, time of clinical sign continued, hematological and serum biochemical values. Where as phenylalanine(over 48.68㎎/㎏ B.W.) given immediately after ochratoxin A appeared to prevent the mortality, body weight time of clinical sign continued, hematological and serum biochemical findings.
The results suggest that the phenylalanine may protect, the subject from ochraloxin A induced acute toxicity.
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